I fold the pad and the Opti-wipes all the time. First thing, go down to the local camera shop and see if they sell the inexpensive cotton glove from handling photos and lenses. These work well and eliminate oils.
If not, just use sugical gloves. Put them on and then wash them with liquid soap and rinse. Dry with a clean towel and you will not have any oils, powder or whatever.
I use the corner of a folded Opti-Wipe to get to the edges of the lens. Pec-Pads will work, but I have to use Opti-Wipes afterward to clean up.
As you said, get all dust off first with air, if possible. Then if needed a VERY LIGHT wipe with a dampened opti-wipe will remove the rest.
Do not use too much fluid, it will run around the edge of the lens. Use just enough to get it clean.
To add to my post above. I have been thinking about how to fold the Pec pad without getting finger oil on it. I have come up with these 2 ways.
1. a. Fold a single sheet of lens paper in half lengthwise, twice. Hold the sheet along its short ends only and do not touch the center.
b. Fold the resulting 3/4" wide strip in half by gently poking its center point.
2. I remove the pad holding it from a corner, and then gather the four corners together forming a small "balloon" of pad material.