I would not be arguing so much for bigger pixels as for a larger sensor.
However, bigger pixels can have some advantages. Given the same technology, a bigger pixel does tend to give better SNR and better dynamic range.
The bigger sensor means you have a bigger FOV (as long as your OTA's image circle is big enough to fully illuminate it). Finding and tracking a target is considerably easier and you can image some of the larger targets.
There can be drawbacks. . . The IMX224 and IMX385 have an amazing SNR1 and you are not likely to equal that with anything except maybe a monochrome IMX183 or possibly something like the monochrome QHY163 (we're not sure how well they compare because Sony has not done the SNR1 ratings for them).
However the IMX294 has very nearly the same SNR1 as do the IMX224 and the IMX385 and has very good dynamic range in a much more generously sized package.
With the Orion 80ED I'd expect quite significant under-sampling with the IMX294 (you're likely under-sampling even with the IMX224) camera but for OAP it really may not matter. For the SCTs the IMX294 cameras would not have a problem with under-sampling - you may have over-sampling but it has so little noise that the over-sampling shouldn't be a significant issue.