I find moving the 10 inch once assembled is not much fun. Like if I had to move it around the yard.
While the 10 has worked out for me in a few different situations (it turns out to be very good for night vision), I think an 8 inch F6 is a more reasonable scope for most situations. I mean, sure, the 10 inch probably does better on DSOs, but I'm not sure it's worth the heft. And being a fast scope it makes it a bit tricky for coma and eyepieces.
It's always hard finding that sweet spot for your largest scope. But for me, above 10 it's going to be truss. And of all the different telescope types, I find above 8 it's going to be a Newtonian. The 8 inch SCT is as large an SCT as I would want. And for refractors, 5 inches is as big as I would go.
Now, as to what size truss scope...I think this is a difficult decision. I was thinking 16 inch. But now I'm thinking maybe that's a bit much. And that may depend on some factors such as mirror thickness, structure weight, etc. I mean, if I was looking at a 12 inch truss it's just too close to my 10 to be worth it. So I'm think 14 is probably the minimum that would be worth it. Since I'm doing a lot of night vision, I'd want an F4 scope most likely.