Thats a lot of gear hanging off the back of the scope. Plus with the scope moving and the off-center nature of the load (e.g. the filter wheel) there is a chance that a loosely threaded item could become looser.
Probably not likely it will fall off, but might ruin my framing (actually just happened now as I was doing my balance test, the filter wheel unscrewed a 1/4 turn on its own) .
Generally (in life) things that are screwed together either have split washers, friction washers, or threadlock to keep them from coming apart.
Should I just be more aggressive with my "hand tightening" or is there a better way to solve this?