My home-built 16-inch dob is built like a Russian tank. I originally finished it in 1987 and literally built it out of junk. I had it equatorially mounted in the back yard in base housing at Incirlik AB in Turkey. Then we moved to Spain (for the third time) and I threw the entire thing out except the optics and focuser and rebuilt it as a Dob in Spain. When we moved back to the You Ess And A, I threw it all away again and built the next version as another Dob in Oklahoma. It lasted through our move to Indiana. Then I trashed it and rebuilt it again when we moved to Las Vegas where it sits under a tarp in the back yard. It's seen a lot of action and rough treatment and yes, I had to align it each use, even when it sat there under a tarp and hadn't moved in months.
Takes a licking and keeps on ticking.
My current 16-inch is a Meade LightBridge and I take it everywhere. It's my grab and go because I don't use anything else, except once in a while, the home built one, which never moves anymore. Too big (it's f/6.4).
That Meade gets moved every time I use it and it also takes a beating and keeps on ticking. A dob isn't a delicate beast.
Oh, and just breathing on a Newtonian warrants an alignment check, or leaving it overnight...usually.