Sean Carroll's Mindscape is the best podcast I have come across. If you are not familiar, it is very smart people having a conversation about big ideas. There is a different topic each episode, sometimes it's cosmology, and sometimes it's economics or anything in-between. I cannot recommend this enough.
For those who may be familiar with Mindscape, do you know of any other podcasts that resemble Mindscape? Dr. Carroll is quite prolific but I am eventually going to catch up with his schedule and then I will only get one episode per week-ish.