So, it's been a bad night
Story setup: I guess the kids got attracted by the big shiny focusing knob. And turned it until the tube was all in.
Now, I changed the IRcut filter to the duoband. Went outside, setup, waited for reasonable dark, polar aligned, then tried to autofocus. No luck, of course. Waited for darker dark, same. Slew around until I was quite sure I was pointing at Vega. All in all, took me a good half hour of uttering unprintable words until I got a disc on my screen about half the size of field of view. Of course, I didn't even tried to run an autofocus sequence, so I keep entering manual values. It improved a bit, than stopped. Took me 10 minutes or more to notice that the focuser reached the calibration limit and it won't pull the tube more. I am lucky enough I don't have to disconnect my Sesto Senso, so I manually got closer to focus, then finally did the autofocus routine. Took my flats. Started my sequence and ran inside to doctor my mosquito stings.
Guiding was not great, so I took a peek at the guide camera images... quite very out of focus. It's been 42 Celsius here, and even at the beginning of the night there were 29C. Didn't stop the sequence and went outside to refocus the guide camera. Not trivial with varifocal glasses, let me tell you. Did a reasonable job with that, went inside, waited for the camera to finish it's 5 min image (which was, of course, very shaky).
Well, next image had some very bad DEC excursions. Cursed a bit, waited 5 more minutes... worse. Stopped and restarted guiding. Same. Closed PHD and guide camera interface software, reconnected from NINA, same. Or worse.
This persisted until I stopped the sequence and restarted it. What could have caused this dance? I did not recalibrate guiding. Guide camera is very solidly attached to the mount (iOptron guider system).

