I have an 8' dome housing a 64" refractor, and it is tight. You can think of that as 16" on each end, but I have it shifted forward to clear the dome by only 8", which should allow 24" behind it. Even so, depending on the position, I still can't stand behind it to look through the eyepiece -- just the nature of the equatorial mount. I was also an operator for the Amherst College 18" Clark for public observing nights. That dome allows 8' behind the eyepiece, and has a motorized platform that lifts observers over 12' up.
You will want the eyepiece to be far enough off the ground to be comfortable for viewing above 45* altitude. With a mount axis height of 9'9", the tailpiece will be about 4'3" below the mount axis at 45* and 5'9" below when at the zenith, that keeps the eyepiece in a range of 5'6" to 4' at those altitudes. For angles below that, you'll want a rolling stair.
For an observatory that will house a 12' telescope and serve visitors, I would thus advise at least 4' of space behind the eyepiece because the stair unit should have enough space for an operator and a visitor to stand on (including a parent and child). They don't all have to stand behind the scope -- the operator can be beside it while visitors look. You want to avoid the situation where the eyepiece is over 7' off the ground, and the operator can't reach it to help the visitor or prevent an accident. Thus, that would argue for a 20' dome at least.
As to the height of the stair, near the horizon, the eyepiece will be above 9', but you're unlikely to do much in that part of the sky except for some planet viewing if you have unobstructed views. So the stairs might only provide 24 to 30" of rise to a platform, and then you could have a portable step to bridge the gap for short viewers or closer to the horizon.
At that size, the dome doesn't have to be on a wall at the height of the mount. Because it is nearly vertical for several feet at the sides, you could use a wall that's just high enough for the entry door, and that can even be a bit less than full height. So you could have the dome on a wall that's 7' high.
It's also good to have some space outside of the circle of the dome, both for equipment storage, and for people to get out of the way while the scope is being moved. Given the weight of the dome, you'll probably want a circular support structure, and the extra space can be in a wing or wings off of that.
Chip W.